Drug interactions
Hydrochlorothiazide-lisinopril + Potassium citrate
Severity: Moderate
Hydrochlorothiazide-lisinopril and Potassium citrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium supplements combined with an ACE inhibitor can cause hyperkalemia, and the potassium-wasting effect of hydrochlorothiazide only partly offsets this. Risk is greater with renal impairment, diabetes or older age.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Potassium citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Potassium citrate belongs to Gastrointestinal Tract.
Why it happens
Added potassium load combined with reduced aldosterone-mediated potassium excretion from lisinopril.
What to do
Monitor serum potassium and renal function at the start of therapy and periodically afterward, and reduce or stop potassium citrate if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Potassium citrate
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Potassium citrate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Potassium citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium supplements combined with an ACE inhibitor can cause hyperkalemia, and the potassium-wasting effect of hydrochlorothiazide only partly offsets this. Risk is greater with renal impairment, diabetes or older age.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Potassium citrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function at the start of therapy and periodically afterward, and reduce or stop potassium citrate if potassium rises.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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