Drug interactions
Hydrochlorothiazide-lisinopril + Probenecid
Severity: Moderate
Hydrochlorothiazide-lisinopril and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides raise serum uric acid and can oppose the uricosuric effect of probenecid, reducing its efficacy in gout. Probenecid may also raise hydrochlorothiazide levels by reducing its renal secretion.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Thiazide-induced reduction in urate excretion and competition for renal tubular organic anion secretion between the two drugs.
What to do
Monitor serum uric acid and gout control, and adjust the probenecid dose if needed. Consider an alternative antihypertensive in patients with difficult gout.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-lisinopril and Probenecid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Probenecid?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides raise serum uric acid and can oppose the uricosuric effect of probenecid, reducing its efficacy in gout. Probenecid may also raise hydrochlorothiazide levels by reducing its renal secretion.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout control, and adjust the probenecid dose if needed. Consider an alternative antihypertensive in patients with difficult gout.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
