Drug interactions
Hydrochlorothiazide-lisinopril + Verapamil
Severity: Minor
Hydrochlorothiazide-lisinopril and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both lisinopril and hydrochlorothiazide lower blood pressure, and verapamil adds further vasodilation and negative chronotropic effect. The combination is commonly used, but hypotension, dizziness and bradycardia can occur, especially at initiation or in older patients.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering; any renal tubular competition effect on verapamil is of uncertain significance.
What to do
Monitor blood pressure and heart rate when starting or adjusting doses. Reduce doses if symptomatic hypotension or bradycardia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Verapamil?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both lisinopril and hydrochlorothiazide lower blood pressure, and verapamil adds further vasodilation and negative chronotropic effect. The combination is commonly used, but hypotension, dizziness and bradycardia can occur, especially at initiation or in older patients.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting doses. Reduce doses if symptomatic hypotension or bradycardia develops.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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