Drug interactions
Hydrochlorothiazide-losartan + Iloperidone
Severity: Minor
Hydrochlorothiazide-losartan and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone weakly inhibits CYP3A4 and may modestly alter losartan metabolism. Both drugs can lower blood pressure, so additive hypotension and orthostasis are of greater practical concern.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Iloperidone belongs to Central Nervous System.
Why it happens
Additive alpha-adrenergic blockade and hypotensive effects, with possible minor CYP3A4 inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when iloperidone is started or titrated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Iloperidone?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone weakly inhibits CYP3A4 and may modestly alter losartan metabolism. Both drugs can lower blood pressure, so additive hypotension and orthostasis are of greater practical concern.
How serious is the interaction between Hydrochlorothiazide-losartan and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when iloperidone is started or titrated.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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