Drug interactions
Hydrochlorothiazide-losartan + Liraglutide
Severity: Minor
Hydrochlorothiazide-losartan and Liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can worsen glucose tolerance and offset part of liraglutide's glucose-lowering effect. Losartan may slightly improve insulin sensitivity. Fluid losses from GLP-1 related gastrointestinal effects with a diuretic and ARB may also raise the risk of kidney injury.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Liraglutide belongs to Endocrine.
Why it happens
Thiazide-induced impairment of insulin secretion and sensitivity opposes GLP-1 receptor agonism, while ARBs may modestly improve insulin sensitivity.
What to do
Monitor glycemic control when the thiazide dose is changed. Counsel patients to maintain hydration if vomiting or diarrhea occurs and check renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Liraglutide?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can worsen glucose tolerance and offset part of liraglutide's glucose-lowering effect. Losartan may slightly improve insulin sensitivity. Fluid losses from GLP-1 related gastrointestinal effects with a diuretic and ARB may also raise the risk of kidney injury.
How serious is the interaction between Hydrochlorothiazide-losartan and Liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when the thiazide dose is changed. Counsel patients to maintain hydration if vomiting or diarrhea occurs and check renal function.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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