Drug interactions
Hydrochlorothiazide-losartan + Lomitapide
Severity: Moderate
Hydrochlorothiazide-losartan and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a CYP3A4 substrate with hepatotoxic potential, and weak CYP3A4 inhibitors can raise its exposure. Both drugs can increase liver enzymes, so the combination could add to hepatic risk.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition by losartan raises lomitapide levels, with additive hepatic enzyme elevation.
What to do
Monitor liver enzymes per lomitapide labeling and keep the lomitapide dose within labeled limits when weak CYP3A4 inhibitors are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-losartan and Lomitapide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Lomitapide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is a CYP3A4 substrate with hepatotoxic potential, and weak CYP3A4 inhibitors can raise its exposure. Both drugs can increase liver enzymes, so the combination could add to hepatic risk.
How serious is the interaction between Hydrochlorothiazide-losartan and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes per lomitapide labeling and keep the lomitapide dose within labeled limits when weak CYP3A4 inhibitors are used.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
