Drug interactions
Hydrochlorothiazide-losartan + Memantine
Severity: Minor
Hydrochlorothiazide-losartan and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is partly eliminated by renal tubular secretion, and hydrochlorothiazide may reduce its clearance slightly. Labeling notes that the thiazide combination may lower hydrochlorothiazide exposure rather than raise memantine meaningfully, so the clinical effect is small.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Memantine belongs to Central Nervous System.
Why it happens
Possible competition for renal tubular cationic secretion.
What to do
No dose change is usually needed; watch for dizziness or confusion in elderly patients with reduced renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Memantine?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is partly eliminated by renal tubular secretion, and hydrochlorothiazide may reduce its clearance slightly. Labeling notes that the thiazide combination may lower hydrochlorothiazide exposure rather than raise memantine meaningfully, so the clinical effect is small.
How serious is the interaction between Hydrochlorothiazide-losartan and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for dizziness or confusion in elderly patients with reduced renal function.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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