Drug interactions
Hydrochlorothiazide-losartan + Omeprazole
Severity: Minor
Hydrochlorothiazide-losartan and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole is metabolised by and can inhibit CYP2C19 and, to a lesser extent, CYP2C9, which may theoretically reduce conversion of losartan to its active metabolite. No clinically important effect on blood pressure has been demonstrated.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Possible weak CYP2C9 inhibition altering losartan activation; clinical relevance not established.
What to do
No routine adjustment needed; monitor blood pressure if omeprazole is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Omeprazole?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omeprazole is metabolised by and can inhibit CYP2C19 and, to a lesser extent, CYP2C9, which may theoretically reduce conversion of losartan to its active metabolite. No clinically important effect on blood pressure has been demonstrated.
How serious is the interaction between Hydrochlorothiazide-losartan and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; monitor blood pressure if omeprazole is started or stopped.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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