Drug interactions
Hydrochlorothiazide-losartan + Potassium iodide
Severity: Minor
Hydrochlorothiazide-losartan and Potassium iodide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium iodide supplies a potassium load, and losartan reduces renal potassium excretion, so hyperkalemia is possible. The risk is greater with renal impairment, and short-term or low doses carry less risk.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Potassium iodide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Potassium iodide belongs to Endocrine.
Why it happens
Added potassium load with ARB-reduced aldosterone-driven potassium excretion.
What to do
Check serum potassium if potassium iodide is used for prolonged periods or in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Potassium iodide?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Potassium iodide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Potassium iodide supplies a potassium load, and losartan reduces renal potassium excretion, so hyperkalemia is possible. The risk is greater with renal impairment, and short-term or low doses carry less risk.
How serious is the interaction between Hydrochlorothiazide-losartan and Potassium iodide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium if potassium iodide is used for prolonged periods or in renal impairment.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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