Drug interactions
Hydrochlorothiazide-losartan + Ribociclib
Severity: Moderate
Hydrochlorothiazide-losartan and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4, which contributes to losartan activation and clearance, so the effect on losartan is unclear and probably small. Ribociclib also prolongs QT, and hydrochlorothiazide-induced electrolyte loss can add to that risk.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Ribociclib belongs to Oncology.
Why it happens
CYP3A4 inhibition by ribociclib alters losartan metabolism; thiazide electrolyte loss adds to ribociclib QT prolongation.
What to do
Check and correct potassium and magnesium before and during ribociclib therapy, and monitor ECG and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Ribociclib?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4, which contributes to losartan activation and clearance, so the effect on losartan is unclear and probably small. Ribociclib also prolongs QT, and hydrochlorothiazide-induced electrolyte loss can add to that risk.
How serious is the interaction between Hydrochlorothiazide-losartan and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during ribociclib therapy, and monitor ECG and blood pressure.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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