Drug interactions
Hydrochlorothiazide-losartan + Succinylcholine
Severity: Moderate
Hydrochlorothiazide-losartan and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine can transiently raise serum potassium, while thiazide-induced electrolyte disturbances and losartan's potassium retention can alter potassium balance perioperatively. Hypokalemia may also change neuromuscular blockade response and arrhythmia risk.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Succinylcholine depolarisation releases potassium, combined with diuretic and ARB effects on potassium homeostasis.
What to do
Check serum potassium and correct abnormalities before elective surgery requiring succinylcholine. Monitor ECG and neuromuscular function during anaesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-losartan and Succinylcholine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Succinylcholine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Succinylcholine can transiently raise serum potassium, while thiazide-induced electrolyte disturbances and losartan's potassium retention can alter potassium balance perioperatively. Hypokalemia may also change neuromuscular blockade response and arrhythmia risk.
How serious is the interaction between Hydrochlorothiazide-losartan and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and correct abnormalities before elective surgery requiring succinylcholine. Monitor ECG and neuromuscular function during anaesthesia.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
