Drug interactions
Hydrochlorothiazide-losartan + Tazemetostat
Severity: Minor
Hydrochlorothiazide-losartan and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and a CYP3A4 substrate, and losartan is partly metabolized by CYP3A4 and CYP2C9. Any change in exposure is expected to be small and the clinical effect is uncertain.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by tazemetostat may slightly lower losartan activation or clearance.
What to do
No routine dose change is needed. Monitor blood pressure if there is a loss of control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-losartan and Tazemetostat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Tazemetostat?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and a CYP3A4 substrate, and losartan is partly metabolized by CYP3A4 and CYP2C9. Any change in exposure is expected to be small and the clinical effect is uncertain.
How serious is the interaction between Hydrochlorothiazide-losartan and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor blood pressure if there is a loss of control.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
