Drug interactions
Hydrochlorothiazide-losartan + Torsemide
Severity: Moderate
Hydrochlorothiazide-losartan and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding torsemide to a thiazide-containing regimen produces additive diuresis, which can lead to volume depletion, hypotension, hypokalemia, hyponatremia and renal impairment. Losartan may partly offset potassium loss but also raises the risk of renal dysfunction when volume depleted.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Why it happens
Sequential nephron blockade by loop and thiazide diuretics gives additive natriuresis and potassium loss, with angiotensin receptor blockade adding hemodynamic effects.
What to do
Monitor electrolytes, creatinine, weight and blood pressure after starting or changing doses. Reduce the diuretic dose if volume depletion or electrolyte disturbance occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Torsemide
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Torsemide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding torsemide to a thiazide-containing regimen produces additive diuresis, which can lead to volume depletion, hypotension, hypokalemia, hyponatremia and renal impairment. Losartan may partly offset potassium loss but also raises the risk of renal dysfunction when volume depleted.
How serious is the interaction between Hydrochlorothiazide-losartan and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, creatinine, weight and blood pressure after starting or changing doses. Reduce the diuretic dose if volume depletion or electrolyte disturbance occurs.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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