Drug interactions
Hydrochlorothiazide-losartan + Voriconazole
Severity: Minor
Hydrochlorothiazide-losartan and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP2C9 and CYP3A4, which convert losartan to its more potent active metabolite E-3174. Exposure to the active metabolite may fall, which could reduce the antihypertensive effect, though the clinical importance is not firmly established.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-losartan belongs to Cardiovascular; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP2C9 and CYP3A4 reduces conversion of losartan to its active carboxylic acid metabolite.
What to do
Monitor blood pressure when voriconazole is started or stopped. Adjust the losartan dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Voriconazole?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole inhibits CYP2C9 and CYP3A4, which convert losartan to its more potent active metabolite E-3174. Exposure to the active metabolite may fall, which could reduce the antihypertensive effect, though the clinical importance is not firmly established.
How serious is the interaction between Hydrochlorothiazide-losartan and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when voriconazole is started or stopped. Adjust the losartan dose if control is lost.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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