Drug interactions
Hydrochlorothiazide-olmesartan + Maraviroc
Severity: Moderate
Hydrochlorothiazide-olmesartan and Maraviroc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc can cause postural hypotension, and this may add to the blood pressure lowering of olmesartan and hydrochlorothiazide. Risk is greatest in patients with renal impairment or on other antihypertensives.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Maraviroc belongs to Anti Virals.
Why it happens
Additive hypotensive effects; maraviroc's postural hypotension adds to the vasodilatory and volume-depleting effects of the antihypertensives.
What to do
Monitor orthostatic blood pressure when starting maraviroc and counsel patients to rise slowly. Reduce antihypertensive doses if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Maraviroc?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc can cause postural hypotension, and this may add to the blood pressure lowering of olmesartan and hydrochlorothiazide. Risk is greatest in patients with renal impairment or on other antihypertensives.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Maraviroc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when starting maraviroc and counsel patients to rise slowly. Reduce antihypertensive doses if symptomatic hypotension develops.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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