Drug interactions
Hydrochlorothiazide-olmesartan + Toremifene
Severity: Moderate
Hydrochlorothiazide-olmesartan and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene can cause hypercalcemia, especially in patients with bone metastases, and thiazides reduce urinary calcium excretion. Together they can raise serum calcium further.
What this interaction means in plain words
Hydrochlorothiazide-olmesartan and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-olmesartan belongs to Cardiovascular; Toremifene belongs to Endocrine.
Why it happens
Thiazide-enhanced renal calcium reabsorption adds to toremifene-associated hypercalcemia.
What to do
Monitor serum calcium early in therapy and consider an alternative antihypertensive if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-olmesartan with Toremifene?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-olmesartan and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Toremifene can cause hypercalcemia, especially in patients with bone metastases, and thiazides reduce urinary calcium excretion. Together they can raise serum calcium further.
How serious is the interaction between Hydrochlorothiazide-olmesartan and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium early in therapy and consider an alternative antihypertensive if hypercalcemia develops.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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