Drug interactions
Hydrochlorothiazide-telmisartan + Pretomanid
Severity: Minor
Hydrochlorothiazide-telmisartan and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits OATP1B3 in vitro, and telmisartan is an OATP1B3 substrate, so telmisartan exposure may increase. The clinical impact is expected to be modest, as telmisartan has a wide therapeutic margin.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Why it happens
Inhibition of OATP1B3-mediated hepatic uptake of telmisartan by pretomanid.
What to do
No empirical dose change is needed; monitor blood pressure and watch for hypotension or adverse effects of telmisartan during pretomanid therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Pretomanid?
MediHelp rates the interaction as minor. Hydrochlorothiazide-telmisartan and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits OATP1B3 in vitro, and telmisartan is an OATP1B3 substrate, so telmisartan exposure may increase. The clinical impact is expected to be modest, as telmisartan has a wide therapeutic margin.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor blood pressure and watch for hypotension or adverse effects of telmisartan during pretomanid therapy.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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