Drug interactions
Hydrochlorothiazide-telmisartan + Sotalol
Severity: Major
Hydrochlorothiazide-telmisartan and Sotalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide-induced hypokalemia or hypomagnesemia increases the risk of QT prolongation and torsades de pointes with sotalol. Additive hypotension and bradycardia can also occur.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Diuretic-induced electrolyte depletion potentiates sotalol's QT prolongation, with additive hemodynamic effects.
What to do
Check and correct potassium and magnesium before and during sotalol therapy. Monitor ECG for QT interval, heart rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Sotalol?
MediHelp rates the interaction as major. Hydrochlorothiazide-telmisartan and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Hydrochlorothiazide-induced hypokalemia or hypomagnesemia increases the risk of QT prolongation and torsades de pointes with sotalol. Additive hypotension and bradycardia can also occur.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during sotalol therapy. Monitor ECG for QT interval, heart rate and blood pressure.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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