Drug interactions
Hydrochlorothiazide-telmisartan + Vadadustat
Severity: Minor
Hydrochlorothiazide-telmisartan and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat is an OAT3 and OAT1 substrate, and telmisartan may inhibit these transporters, which may raise vadadustat exposure. This could lead to an excessive or rapid hemoglobin rise with attendant thrombotic and cardiovascular risk.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Vadadustat belongs to Endocrine.
Why it happens
Possible inhibition of OAT1/OAT3-mediated renal secretion of vadadustat by telmisartan.
What to do
Monitor hemoglobin as per vadadustat labeling and reduce the vadadustat dose if hemoglobin rises too quickly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Vadadustat?
MediHelp rates the interaction as minor. Hydrochlorothiazide-telmisartan and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat is an OAT3 and OAT1 substrate, and telmisartan may inhibit these transporters, which may raise vadadustat exposure. This could lead to an excessive or rapid hemoglobin rise with attendant thrombotic and cardiovascular risk.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin as per vadadustat labeling and reduce the vadadustat dose if hemoglobin rises too quickly.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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