Drug interactions
Hydrochlorothiazide-telmisartan + Vitamin d
Severity: Moderate
Hydrochlorothiazide-telmisartan and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium excretion, and combined with vitamin D or its analogues this can cause hypercalcemia. The risk is higher with high-dose vitamin D, calcium supplements or renal impairment.
What this interaction means in plain words
Hydrochlorothiazide-telmisartan and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-telmisartan belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Thiazides increase renal calcium reabsorption while vitamin D increases intestinal calcium absorption, leading to additive elevation of serum calcium.
What to do
Monitor serum calcium periodically, especially when starting or increasing vitamin D doses. Reduce vitamin D or calcium supplements if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-telmisartan and Vitamin d, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Vitamin d
Frequently asked questions
Can I take Hydrochlorothiazide-telmisartan with Vitamin d?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-telmisartan and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, and combined with vitamin D or its analogues this can cause hypercalcemia. The risk is higher with high-dose vitamin D, calcium supplements or renal impairment.
How serious is the interaction between Hydrochlorothiazide-telmisartan and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, especially when starting or increasing vitamin D doses. Reduce vitamin D or calcium supplements if hypercalcemia develops.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
