Drug interactions
Hydrochlorothiazide-valsartan + Levoketoconazole
Severity: Minor
Hydrochlorothiazide-valsartan and Levoketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is taken up by hepatic OATP1B1, so inhibitors could modestly raise its exposure. The effect of levoketoconazole on valsartan is theoretical and unlikely to be significant.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Levoketoconazole belongs to Endocrine.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of valsartan.
What to do
No routine adjustment is required; monitor blood pressure and potassium when therapy begins.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Levoketoconazole?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is taken up by hepatic OATP1B1, so inhibitors could modestly raise its exposure. The effect of levoketoconazole on valsartan is theoretical and unlikely to be significant.
How serious is the interaction between Hydrochlorothiazide-valsartan and Levoketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor blood pressure and potassium when therapy begins.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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