Drug interactions
Hydrochlorothiazide-valsartan + Vadadustat
Severity: Minor
Hydrochlorothiazide-valsartan and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat is a substrate of OAT3, and valsartan may inhibit this transporter. Exposure to vadadustat could rise, increasing the hemoglobin response.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of OAT1/OAT3-mediated renal handling of vadadustat reduces its clearance.
What to do
Monitor hemoglobin and adjust the vadadustat dose per labeling if the rise is too rapid.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Vadadustat?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat is a substrate of OAT3, and valsartan may inhibit this transporter. Exposure to vadadustat could rise, increasing the hemoglobin response.
How serious is the interaction between Hydrochlorothiazide-valsartan and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and adjust the vadadustat dose per labeling if the rise is too rapid.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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