Drug interactions
Hydrocodone + Iloperidone
Severity: Moderate
Hydrocodone and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is sedating and can add to the CNS depression and hypotension from hydrocodone. Both drugs may also affect cognition and alertness.
What this interaction means in plain words
Hydrocodone and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and alpha-adrenergic related hypotension; iloperidone is partly metabolized by CYP3A4, which opioids do not meaningfully alter.
What to do
Start low and titrate carefully, monitoring sedation, orthostatic blood pressure and respiratory status. Counsel patients about impaired alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Hydrocodone with Iloperidone?
MediHelp rates the interaction as moderate. Hydrocodone and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is sedating and can add to the CNS depression and hypotension from hydrocodone. Both drugs may also affect cognition and alertness.
How serious is the interaction between Hydrocodone and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start low and titrate carefully, monitoring sedation, orthostatic blood pressure and respiratory status. Counsel patients about impaired alertness.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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