Drug interactions
Hydrocodone + Ribociclib
Severity: Moderate
Hydrocodone and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4, the main pathway clearing hydrocodone, so hydrocodone exposure may rise. This can increase sedation and respiratory depression. Ribociclib also prolongs the QT interval, which adds complexity.
What this interaction means in plain words
Hydrocodone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Ribociclib belongs to Oncology.
Why it happens
CYP3A4 inhibition by ribociclib decreases hydrocodone clearance.
What to do
Monitor for sedation and respiratory depression and consider reducing the hydrocodone dose. Reassess the opioid dose when ribociclib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Hydrocodone with Ribociclib?
MediHelp rates the interaction as moderate. Hydrocodone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4, the main pathway clearing hydrocodone, so hydrocodone exposure may rise. This can increase sedation and respiratory depression. Ribociclib also prolongs the QT interval, which adds complexity.
How serious is the interaction between Hydrocodone and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and consider reducing the hydrocodone dose. Reassess the opioid dose when ribociclib is stopped.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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