Drug interactions
Hydrocodone + Tazemetostat
Severity: Minor
Hydrocodone and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and may modestly lower hydrocodone concentrations, potentially reducing analgesia. Withdrawal of tazemetostat may raise levels again.
What this interaction means in plain words
Hydrocodone and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocodone belongs to Musculoskeletal; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction increases hydrocodone clearance.
What to do
Monitor pain control and adjust hydrocodone if needed; watch for increased opioid effects after tazemetostat is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Hydrocodone with Tazemetostat?
MediHelp rates the interaction as minor. Hydrocodone and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and may modestly lower hydrocodone concentrations, potentially reducing analgesia. Withdrawal of tazemetostat may raise levels again.
How serious is the interaction between Hydrocodone and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and adjust hydrocodone if needed; watch for increased opioid effects after tazemetostat is stopped.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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