Drug interactions
Hydrocortisone + Maraviroc
Severity: Minor
Hydrocortisone and Maraviroc: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is a CYP3A4 substrate, and corticosteroids may weakly induce this enzyme. Any reduction in maraviroc exposure is likely small. Both agents may also add to immunosuppression or infection risk in some settings.
What this interaction means in plain words
Hydrocortisone and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Maraviroc belongs to Anti Virals.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone, increasing maraviroc metabolism.
What to do
No routine dose adjustment is needed. Monitor HIV viral load if hydrocortisone is given at high doses for a prolonged period.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Hydrocortisone with Maraviroc?
MediHelp rates the interaction as minor. Hydrocortisone and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maraviroc is a CYP3A4 substrate, and corticosteroids may weakly induce this enzyme. Any reduction in maraviroc exposure is likely small. Both agents may also add to immunosuppression or infection risk in some settings.
How serious is the interaction between Hydrocortisone and Maraviroc?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Monitor HIV viral load if hydrocortisone is given at high doses for a prolonged period.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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