Drug interactions
Hydrocortisone + Posaconazole
Severity: Moderate
Hydrocortisone and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole strongly inhibits CYP3A4 and can increase systemic hydrocortisone exposure, raising the risk of Cushingoid effects and adrenal suppression with prolonged use. Exposure increase is relevant mainly with systemic dosing.
What this interaction means in plain words
Hydrocortisone and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibition of CYP3A4-mediated hydrocortisone metabolism.
What to do
Monitor for corticosteroid excess such as hyperglycemia, edema and hypertension, and reduce the hydrocortisone dose if needed. Be aware of adrenal suppression when stopping.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Hydrocortisone with Posaconazole?
MediHelp rates the interaction as moderate. Hydrocortisone and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole strongly inhibits CYP3A4 and can increase systemic hydrocortisone exposure, raising the risk of Cushingoid effects and adrenal suppression with prolonged use. Exposure increase is relevant mainly with systemic dosing.
How serious is the interaction between Hydrocortisone and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess such as hyperglycemia, edema and hypertension, and reduce the hydrocortisone dose if needed. Be aware of adrenal suppression when stopping.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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