Drug interactions
Hydrocortisone + Tucatinib
Severity: Moderate
Hydrocortisone and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-glycoprotein, which could modestly raise hydrocortisone exposure. Tucatinib also inhibits CYP3A4, adding to this effect. Clinically meaningful glucocorticoid excess is most likely with long-term or high-dose use.
What this interaction means in plain words
Hydrocortisone and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits P-gp and CYP3A4, reducing hydrocortisone efflux and metabolism.
What to do
Monitor for signs of glucocorticoid excess during prolonged co-use and consider reducing the hydrocortisone dose if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Hydrocortisone with Tucatinib?
MediHelp rates the interaction as moderate. Hydrocortisone and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits P-glycoprotein, which could modestly raise hydrocortisone exposure. Tucatinib also inhibits CYP3A4, adding to this effect. Clinically meaningful glucocorticoid excess is most likely with long-term or high-dose use.
How serious is the interaction between Hydrocortisone and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of glucocorticoid excess during prolonged co-use and consider reducing the hydrocortisone dose if they appear.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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