Drug interactions
Hydrocortisone + Ubrogepant
Severity: Minor
Hydrocortisone and Ubrogepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is a weak CYP3A4 inducer at most, and ubrogepant is a CYP3A4 substrate. Exposure to ubrogepant could fall slightly, but the effect is unlikely to matter at usual doses.
What this interaction means in plain words
Hydrocortisone and Ubrogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Ubrogepant belongs to Central Nervous System.
Why it happens
Possible weak induction of CYP3A4 increases ubrogepant metabolism.
What to do
No dose adjustment is generally needed. If migraine control is poor during prolonged high-dose steroid use, consider whether reduced ubrogepant efficacy contributes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Hydrocortisone with Ubrogepant?
MediHelp rates the interaction as minor. Hydrocortisone and Ubrogepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is a weak CYP3A4 inducer at most, and ubrogepant is a CYP3A4 substrate. Exposure to ubrogepant could fall slightly, but the effect is unlikely to matter at usual doses.
How serious is the interaction between Hydrocortisone and Ubrogepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. If migraine control is poor during prolonged high-dose steroid use, consider whether reduced ubrogepant efficacy contributes.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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