Drug interactions
Hydrocortisone + Vildagliptin
Severity: Moderate
Hydrocortisone and Vildagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic hydrocortisone increases blood glucose and can counteract the glucose-lowering effect of vildagliptin. Glycemic control may worsen during corticosteroid courses.
What this interaction means in plain words
Hydrocortisone and Vildagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Vildagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: glucocorticoid-induced insulin resistance and increased hepatic glucose production oppose DPP-4 inhibition.
What to do
Monitor blood glucose during systemic hydrocortisone therapy and intensify antidiabetic treatment if needed, then reassess when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Vildagliptin
- Ciprofloxacin + Vildagliptin Moderate
- Deflazacort + Vildagliptin Moderate
- Dexamethasone + Vildagliptin Moderate
- Gemifloxacin + Vildagliptin Moderate
- Glimepiride + Vildagliptin Moderate
- Hydrochlorothiazide-lisinopril + Vildagliptin Moderate
Frequently asked questions
Can I take Hydrocortisone with Vildagliptin?
MediHelp rates the interaction as moderate. Hydrocortisone and Vildagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic hydrocortisone increases blood glucose and can counteract the glucose-lowering effect of vildagliptin. Glycemic control may worsen during corticosteroid courses.
How serious is the interaction between Hydrocortisone and Vildagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during systemic hydrocortisone therapy and intensify antidiabetic treatment if needed, then reassess when the steroid is tapered.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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