Drug interactions
Gemifloxacin + Vildagliptin
Severity: Moderate
Gemifloxacin and Vildagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients receiving antidiabetic therapy. Vildagliptin alone carries a low hypoglycemia risk, but glucose control may become unpredictable during a course of gemifloxacin.
What this interaction means in plain words
Gemifloxacin and Vildagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Vildagliptin belongs to Endocrine.
Why it happens
Fluoroquinolones alter pancreatic beta-cell insulin release, producing dysglycemia that adds to the glucose-lowering effect of the DPP-4 inhibitor.
What to do
Monitor blood glucose more frequently while on gemifloxacin and advise the patient on symptoms of low and high blood sugar. Stop the antibiotic and review therapy if significant dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Vildagliptin
- Ciprofloxacin + Vildagliptin Moderate
- Deflazacort + Vildagliptin Moderate
- Dexamethasone + Vildagliptin Moderate
- Glimepiride + Vildagliptin Moderate
- Hydrochlorothiazide-lisinopril + Vildagliptin Moderate
- Hydrocortisone + Vildagliptin Moderate
Frequently asked questions
Can I take Gemifloxacin with Vildagliptin?
MediHelp rates the interaction as moderate. Gemifloxacin and Vildagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients receiving antidiabetic therapy. Vildagliptin alone carries a low hypoglycemia risk, but glucose control may become unpredictable during a course of gemifloxacin.
How serious is the interaction between Gemifloxacin and Vildagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently while on gemifloxacin and advise the patient on symptoms of low and high blood sugar. Stop the antibiotic and review therapy if significant dysglycemia occurs.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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