Drug interactions
Ciprofloxacin + Vildagliptin
Severity: Moderate
Ciprofloxacin and Vildagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones such as ciprofloxacin can cause both hypoglycemia and hyperglycemia, particularly in patients on antidiabetic therapy. Vildagliptin alone carries a low hypoglycemia risk, but glucose control may become unpredictable when it is combined with ciprofloxacin.
What this interaction means in plain words
Ciprofloxacin and Vildagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciprofloxacin belongs to Anti Bacterial; Vildagliptin belongs to Endocrine.
Why it happens
Fluoroquinolones disturb pancreatic beta-cell insulin release and glucose homeostasis, producing additive or opposing pharmacodynamic effects on glycemic control.
What to do
Monitor blood glucose closely when ciprofloxacin is started or stopped, and counsel the patient on symptoms of hypoglycemia and hyperglycemia. Stop the quinolone and choose another antibiotic if significant dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Vildagliptin
- Deflazacort + Vildagliptin Moderate
- Dexamethasone + Vildagliptin Moderate
- Gemifloxacin + Vildagliptin Moderate
- Glimepiride + Vildagliptin Moderate
- Hydrochlorothiazide-lisinopril + Vildagliptin Moderate
- Hydrocortisone + Vildagliptin Moderate
Frequently asked questions
Can I take Ciprofloxacin with Vildagliptin?
MediHelp rates the interaction as moderate. Ciprofloxacin and Vildagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones such as ciprofloxacin can cause both hypoglycemia and hyperglycemia, particularly in patients on antidiabetic therapy. Vildagliptin alone carries a low hypoglycemia risk, but glucose control may become unpredictable when it is combined with ciprofloxacin.
How serious is the interaction between Ciprofloxacin and Vildagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when ciprofloxacin is started or stopped, and counsel the patient on symptoms of hypoglycemia and hyperglycemia. Stop the quinolone and choose another antibiotic if significant dysglycemia occurs.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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