Drug interactions
Deflazacort + Vildagliptin
Severity: Moderate
Deflazacort and Vildagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids raise blood glucose and can reduce the glucose-lowering effect of antidiabetic agents such as vildagliptin. Glycemic control may deteriorate, especially during higher-dose or prolonged deflazacort therapy.
What this interaction means in plain words
Deflazacort and Vildagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Vildagliptin belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance and increased hepatic glucose output antagonize the antihyperglycemic action of vildagliptin.
What to do
Monitor blood glucose and HbA1c when starting, adjusting or stopping deflazacort, and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Vildagliptin
- Ciprofloxacin + Vildagliptin Moderate
- Dexamethasone + Vildagliptin Moderate
- Gemifloxacin + Vildagliptin Moderate
- Glimepiride + Vildagliptin Moderate
- Hydrochlorothiazide-lisinopril + Vildagliptin Moderate
- Hydrocortisone + Vildagliptin Moderate
Frequently asked questions
Can I take Deflazacort with Vildagliptin?
MediHelp rates the interaction as moderate. Deflazacort and Vildagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids raise blood glucose and can reduce the glucose-lowering effect of antidiabetic agents such as vildagliptin. Glycemic control may deteriorate, especially during higher-dose or prolonged deflazacort therapy.
How serious is the interaction between Deflazacort and Vildagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting, adjusting or stopping deflazacort, and adjust antidiabetic therapy as needed.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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