Drug interactions
Hydrochlorothiazide-lisinopril + Vildagliptin
Severity: Moderate
Hydrochlorothiazide-lisinopril and Vildagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and may partly offset the glucose-lowering effect of vildagliptin. Conversely, ACE inhibitors may enhance insulin sensitivity and increase risk of hypoglycemia slightly. Also, ACE inhibitors are associated with a higher risk of angioedema when combined with DPP-4 inhibitors.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Vildagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Vildagliptin belongs to Endocrine.
Why it happens
Thiazide-induced hyperglycemia opposes antidiabetic action, and DPP-4 inhibition reduces breakdown of bradykinin and substance P, which may add to ACE inhibitor angioedema risk.
What to do
Monitor blood glucose and HbA1c after starting or changing the thiazide dose. Counsel the patient to report lip, tongue or facial swelling promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Vildagliptin
- Ciprofloxacin + Vildagliptin Moderate
- Deflazacort + Vildagliptin Moderate
- Dexamethasone + Vildagliptin Moderate
- Gemifloxacin + Vildagliptin Moderate
- Glimepiride + Vildagliptin Moderate
- Hydrocortisone + Vildagliptin Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Vildagliptin?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Vildagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and may partly offset the glucose-lowering effect of vildagliptin. Conversely, ACE inhibitors may enhance insulin sensitivity and increase risk of hypoglycemia slightly. Also, ACE inhibitors are associated with a higher risk of angioedema when combined with DPP-4 inhibitors.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Vildagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the thiazide dose. Counsel the patient to report lip, tongue or facial swelling promptly.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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