Drug interactions
Hydromorphone + Levetiracetam
Severity: Moderate
Hydromorphone and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness, so combined use may increase sedation and impair psychomotor performance. Serious respiratory depression is uncommon but possible at higher opioid doses.
What this interaction means in plain words
Hydromorphone and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydromorphone belongs to Musculoskeletal; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Use the lowest effective hydromorphone dose and monitor for sedation and cognitive impairment. Advise patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Levetiracetam
Frequently asked questions
Can I take Hydromorphone with Levetiracetam?
MediHelp rates the interaction as moderate. Hydromorphone and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and dizziness, so combined use may increase sedation and impair psychomotor performance. Serious respiratory depression is uncommon but possible at higher opioid doses.
How serious is the interaction between Hydromorphone and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hydromorphone dose and monitor for sedation and cognitive impairment. Advise patients to avoid driving until the response is known.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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