Drug interactions
Hydromorphone + Methocarbamol
Severity: Moderate
Hydromorphone and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methocarbamol is a centrally acting muscle relaxant that causes drowsiness and dizziness. With hydromorphone the CNS depressant effects add up, raising the risk of excessive sedation, impaired psychomotor function and falls.
What this interaction means in plain words
Hydromorphone and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydromorphone belongs to Musculoskeletal; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depression.
What to do
Start with the lowest effective doses and monitor for sedation and respiratory depression. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Methocarbamol
Frequently asked questions
Can I take Hydromorphone with Methocarbamol?
MediHelp rates the interaction as moderate. Hydromorphone and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methocarbamol is a centrally acting muscle relaxant that causes drowsiness and dizziness. With hydromorphone the CNS depressant effects add up, raising the risk of excessive sedation, impaired psychomotor function and falls.
How serious is the interaction between Hydromorphone and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and monitor for sedation and respiratory depression. Counsel patients to avoid driving and alcohol.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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