Drug interactions
Hydromorphone + Orphenadrin
Severity: Major
Hydromorphone and Orphenadrin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a centrally acting muscle relaxant increases sedation and may add to respiratory depression. Orphenadrine's anticholinergic effects can also add to opioid-related constipation and urinary retention.
What this interaction means in plain words
Hydromorphone and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydromorphone belongs to Musculoskeletal; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression, with additive anticholinergic effects on gut and bladder.
What to do
Use the lowest effective doses for the shortest time and monitor for sedation and respiratory depression. Counsel the patient against alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Orphenadrin
Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Hydromorphone with Orphenadrin?
MediHelp rates the interaction as major. Hydromorphone and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a centrally acting muscle relaxant increases sedation and may add to respiratory depression. Orphenadrine's anticholinergic effects can also add to opioid-related constipation and urinary retention.
How serious is the interaction between Hydromorphone and Orphenadrin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and monitor for sedation and respiratory depression. Counsel the patient against alcohol and driving.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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