Drug interactions
Hydromorphone + Prasugrel
Severity: Moderate
Hydromorphone and Prasugrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gastric emptying and delay and reduce absorption of oral prasugrel's active metabolite, which can lower early antiplatelet effect. This matters most in acute coronary syndrome and primary PCI.
What this interaction means in plain words
Hydromorphone and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydromorphone belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Opioid-induced delay in gastric emptying reduces the rate and extent of prasugrel absorption.
What to do
Where rapid platelet inhibition is needed, consider a parenteral antiplatelet agent; otherwise use the lowest effective opioid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Prasugrel
Frequently asked questions
Can I take Hydromorphone with Prasugrel?
MediHelp rates the interaction as moderate. Hydromorphone and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gastric emptying and delay and reduce absorption of oral prasugrel's active metabolite, which can lower early antiplatelet effect. This matters most in acute coronary syndrome and primary PCI.
How serious is the interaction between Hydromorphone and Prasugrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where rapid platelet inhibition is needed, consider a parenteral antiplatelet agent; otherwise use the lowest effective opioid dose.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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