Drug interactions
Hydromorphone + Quinidine
Severity: Minor
Hydromorphone and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits CYP2D6, which matters for prodrug opioids such as codeine, but hydromorphone is mainly glucuronidated and is not meaningfully affected. No clinically significant interaction is expected.
What this interaction means in plain words
Hydromorphone and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydromorphone belongs to Musculoskeletal; Quinidine belongs to Anti Parasitic.
Why it happens
CYP2D6 inhibition by quinidine has little effect because hydromorphone is cleared by glucuronidation.
What to do
No dose adjustment is needed; monitor for usual opioid effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Hydromorphone with Quinidine?
MediHelp rates the interaction as minor. Hydromorphone and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine inhibits CYP2D6, which matters for prodrug opioids such as codeine, but hydromorphone is mainly glucuronidated and is not meaningfully affected. No clinically significant interaction is expected.
How serious is the interaction between Hydromorphone and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for usual opioid effects.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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