Drug interactions
Hydromorphone + Ramelteon
Severity: Minor
Hydromorphone and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon is a melatonin receptor agonist that can cause somnolence and dizziness. Additive drowsiness with hydromorphone is possible, although ramelteon has limited respiratory depressant activity.
What this interaction means in plain words
Hydromorphone and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydromorphone belongs to Musculoskeletal; Ramelteon belongs to Central Nervous System.
Why it happens
Additive sedative effects via different receptor systems.
What to do
Monitor for next-day drowsiness and impaired alertness. Counsel patients on avoiding driving until response is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Hydromorphone with Ramelteon?
MediHelp rates the interaction as minor. Hydromorphone and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon is a melatonin receptor agonist that can cause somnolence and dizziness. Additive drowsiness with hydromorphone is possible, although ramelteon has limited respiratory depressant activity.
How serious is the interaction between Hydromorphone and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for next-day drowsiness and impaired alertness. Counsel patients on avoiding driving until response is known.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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