Drug interactions
Hydroxycarbamide + Pralatrexate
Severity: Moderate
Hydroxycarbamide and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow, so combined use may increase the risk of neutropenia, thrombocytopenia and anemia. Pralatrexate also commonly causes mucositis, which may be compounded by hydroxyurea.
What this interaction means in plain words
Hydroxycarbamide and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxycarbamide belongs to Oncology; Pralatrexate belongs to Oncology.
Why it happens
Additive myelosuppression from two antimetabolite agents with different targets.
What to do
Monitor complete blood counts frequently and adjust doses or delay treatment for significant cytopenias. Ensure folic acid and vitamin B12 supplementation with pralatrexate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pralatrexate
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Hydroxycarbamide with Pralatrexate?
MediHelp rates the interaction as moderate. Hydroxycarbamide and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow, so combined use may increase the risk of neutropenia, thrombocytopenia and anemia. Pralatrexate also commonly causes mucositis, which may be compounded by hydroxyurea.
How serious is the interaction between Hydroxycarbamide and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and adjust doses or delay treatment for significant cytopenias. Ensure folic acid and vitamin B12 supplementation with pralatrexate.
What other medicines interact with Pralatrexate?
MediHelp also lists interactions of Pralatrexate with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Pralatrexate page.
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