Drug interactions
Hydroxycarbamide + Ustekinumab
Severity: Moderate
Hydroxycarbamide and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyurea suppresses bone marrow function and ustekinumab modulates immune responses. Together they may increase the risk of infection.
What this interaction means in plain words
Hydroxycarbamide and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxycarbamide belongs to Oncology; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression via myelosuppression and IL-12/23 blockade.
What to do
Monitor blood counts and for signs of infection. Interrupt therapy if serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Hydroxycarbamide with Ustekinumab?
MediHelp rates the interaction as moderate. Hydroxycarbamide and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyurea suppresses bone marrow function and ustekinumab modulates immune responses. Together they may increase the risk of infection.
How serious is the interaction between Hydroxycarbamide and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of infection. Interrupt therapy if serious infection develops.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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