Drug interactions
Hydroxycarbamide + Vinblastine
Severity: Moderate
Hydroxycarbamide and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow, so combined use can deepen neutropenia, anemia and thrombocytopenia. This increases the risk of infection and bleeding.
What this interaction means in plain words
Hydroxycarbamide and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxycarbamide belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Additive myelosuppression through different cytotoxic mechanisms.
What to do
Monitor complete blood counts regularly and adjust doses or delay cycles for cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Hydroxycarbamide with Vinblastine?
MediHelp rates the interaction as moderate. Hydroxycarbamide and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow, so combined use can deepen neutropenia, anemia and thrombocytopenia. This increases the risk of infection and bleeding.
How serious is the interaction between Hydroxycarbamide and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust doses or delay cycles for cytopenias.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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