Drug interactions
Hydroxychloroquine + Insulin degludec-liraglutide
Severity: Moderate
Hydroxychloroquine and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxychloroquine can lower blood glucose and has been associated with hypoglycemia in patients taking insulin or other antidiabetic drugs. Insulin requirements may fall.
What this interaction means in plain words
Hydroxychloroquine and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Probable enhancement of insulin sensitivity and reduced insulin degradation, giving an additive glucose-lowering effect.
What to do
Monitor glucose closely when hydroxychloroquine is started. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxychloroquine can lower blood glucose and has been associated with hypoglycemia in patients taking insulin or other antidiabetic drugs. Insulin requirements may fall.
How serious is the interaction between Hydroxychloroquine and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely when hydroxychloroquine is started. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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