Drug interactions
Hydroxychloroquine + Insulin glargine-lixisenatide
Severity: Moderate
Hydroxychloroquine and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxychloroquine can enhance the glucose-lowering effect of insulin and other antidiabetic drugs and has been linked to hypoglycemia. Patients may need lower antidiabetic doses.
What this interaction means in plain words
Hydroxychloroquine and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Hydroxychloroquine may increase insulin sensitivity and reduce insulin degradation, adding to hypoglycemic effect; the mechanism is not fully established.
What to do
Monitor blood glucose when hydroxychloroquine is started or stopped. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxychloroquine can enhance the glucose-lowering effect of insulin and other antidiabetic drugs and has been linked to hypoglycemia. Patients may need lower antidiabetic doses.
How serious is the interaction between Hydroxychloroquine and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when hydroxychloroquine is started or stopped. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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