Drug interactions
Hydroxychloroquine + Pitolisant
Severity: Moderate
Hydroxychloroquine and Pitolisant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant can modestly prolong the QT interval and its labeling advises avoiding use with other QT-prolonging drugs. Hydroxychloroquine adds to the risk of arrhythmia.
What this interaction means in plain words
Hydroxychloroquine and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Pitolisant belongs to Central Nervous System.
Why it happens
Additive QT prolongation through pharmacodynamic effects.
What to do
Avoid if possible, particularly in patients with cardiac risk factors; otherwise obtain an ECG and monitor electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Hydroxychloroquine with Pitolisant?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant can modestly prolong the QT interval and its labeling advises avoiding use with other QT-prolonging drugs. Hydroxychloroquine adds to the risk of arrhythmia.
How serious is the interaction between Hydroxychloroquine and Pitolisant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, particularly in patients with cardiac risk factors; otherwise obtain an ECG and monitor electrolytes.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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