Drug interactions
Hydroxychloroquine + Praziquantel
Severity: Minor
Hydroxychloroquine and Praziquantel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine has been shown to lower praziquantel bioavailability, and hydroxychloroquine is related but data are lacking. Both drugs may also affect QT, so an interaction cannot be well characterized.
What this interaction means in plain words
Hydroxychloroquine and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydroxychloroquine belongs to Musculoskeletal; Praziquantel belongs to Anti Parasitic.
Why it happens
Mechanism is not established.
What to do
No routine adjustment is needed. Monitor treatment response and consider an ECG if other QT-prolonging drugs are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Frequently asked questions
Can I take Hydroxychloroquine with Praziquantel?
MediHelp rates the interaction as minor. Hydroxychloroquine and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloroquine has been shown to lower praziquantel bioavailability, and hydroxychloroquine is related but data are lacking. Both drugs may also affect QT, so an interaction cannot be well characterized.
How serious is the interaction between Hydroxychloroquine and Praziquantel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor treatment response and consider an ECG if other QT-prolonging drugs are used.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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