Drug interactions
Hydroxychloroquine + Selpercatinib
Severity: Moderate
Hydroxychloroquine and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both selpercatinib and hydroxychloroquine can prolong the QTc interval. Using them together may increase the risk of torsades de pointes, particularly with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Hydroxychloroquine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Selpercatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QTc prolongation.
What to do
Monitor ECG and electrolytes at baseline and periodically during co-therapy, correcting low potassium and magnesium. Reduce or interrupt selpercatinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Hydroxychloroquine with Selpercatinib?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both selpercatinib and hydroxychloroquine can prolong the QTc interval. Using them together may increase the risk of torsades de pointes, particularly with electrolyte disturbance or cardiac disease.
How serious is the interaction between Hydroxychloroquine and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically during co-therapy, correcting low potassium and magnesium. Reduce or interrupt selpercatinib if QTc becomes markedly prolonged.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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