Drug interactions
Hydroxyprogesterone caproate + Posaconazole
Severity: Minor
Hydroxyprogesterone caproate and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may raise hydroxyprogesterone caproate exposure, although clinical consequences are poorly documented. Progestogen-related adverse effects such as fluid retention or injection-site reactions could theoretically increase.
What this interaction means in plain words
Hydroxyprogesterone caproate and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Posaconazole inhibits CYP3A4, which contributes to hydroxyprogesterone caproate metabolism.
What to do
No routine dose change is needed. Monitor for progestogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Posaconazole?
MediHelp rates the interaction as minor. Hydroxyprogesterone caproate and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may raise hydroxyprogesterone caproate exposure, although clinical consequences are poorly documented. Progestogen-related adverse effects such as fluid retention or injection-site reactions could theoretically increase.
How serious is the interaction between Hydroxyprogesterone caproate and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for progestogenic adverse effects.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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