Drug interactions
Hydroxyurea + Infliximab
Severity: Moderate
Hydroxyurea and Infliximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyurea suppresses the bone marrow and infliximab impairs immune defences, so together they may increase the risk of infection. Combined use needs attention to blood counts.
What this interaction means in plain words
Hydroxyurea and Infliximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyurea belongs to Miscellaneous; Infliximab belongs to Musculoskeletal.
Why it happens
Additive immunosuppression and myelosuppression.
What to do
Monitor blood counts and watch for infection. Reduce the hydroxyurea dose if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydroxyurea and Infliximab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Hydroxyurea with Infliximab?
MediHelp rates the interaction as moderate. Hydroxyurea and Infliximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyurea suppresses the bone marrow and infliximab impairs immune defences, so together they may increase the risk of infection. Combined use needs attention to blood counts.
How serious is the interaction between Hydroxyurea and Infliximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for infection. Reduce the hydroxyurea dose if cytopenias develop.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
